8DTW

The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023036

Summary for 8DTW

Entry DOI	10.2210/pdb8dtw/pdb
Descriptor	Protein PA-X, MANGANESE (II) ION, 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide, ... (7 entities in total)
Functional Keywords	nuclease, influenza, inhibitor resistance, viral protein
Biological source	Influenza A virus More
Total number of polymer chains	1
Total formula weight	24579.86
Authors	Cuypers, M.G.,Slavish, J.P.,Rankovic, Z.,White, S.W. (deposition date: 2022-07-26, release date: 2022-09-21, Last modification date: 2024-04-03)
Primary citation	Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W. Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247:115035-115035, 2023 Cited by PubMed: 36603507 DOI: 10.1016/j.ejmech.2022.115035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation