8DTR

Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14

8DTR の概要

• エントリーDOI: 10.2210/pdb8dtr/pdb
• 分子名称: COV30-14 heavy chain, COV30-14 light chain, Spike protein S2' stem helix peptide, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, coronavirus, antibody, stem helix, neutralizing antibody, covid-19, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 98489.84

構造登録者

Lee, C.C.D.,Lin, T.H.,Wilson, I.A. (登録日: 2022-07-26, 公開日: 2022-11-23, 最終更新日: 2023-10-25)

• 主引用文献: Dacon, C.,Peng, L.,Lin, T.H.,Tucker, C.,Lee, C.D.,Cong, Y.,Wang, L.,Purser, L.,Cooper, A.J.R.,Williams, J.K.,Pyo, C.W.,Yuan, M.,Kosik, I.,Hu, Z.,Zhao, M.,Mohan, D.,Peterson, M.,Skinner, J.,Dixit, S.,Kollins, E.,Huzella, L.,Perry, D.,Byrum, R.,Lembirik, S.,Murphy, M.,Zhang, Y.,Yang, E.S.,Chen, M.,Leung, K.,Weinberg, R.S.,Pegu, A.,Geraghty, D.E.,Davidson, E.,Doranz, B.J.,Douagi, I.,Moir, S.,Yewdell, J.W.,Schmaljohn, C.,Crompton, P.D.,Mascola, J.R.,Holbrook, M.R.,Nemazee, D.,Wilson, I.A.,Tan, J.; Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.; Cell Host Microbe, 31:97-, 2023; PubMed: 36347257; DOI: 10.1016/j.chom.2022.10.010

実験手法

X-RAY DIFFRACTION (1.5 Å)