8DSU

Crystal Structure of SARS CoV-2 Mpro with Pfizer Intravenous Inhibitor PF-00835231

Summary for 8DSU

• Entry DOI: 10.2210/pdb8dsu/pdb
• Descriptor: 3C-like proteinase nsp5, GLYCEROL, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, ... (5 entities in total)
• Functional Keywords: coronavirus, covid-19, covid, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, pfizer iv compound, pf-00835231, viral protein, viral protein-hydrolase-inhibitor complex, viral protein/hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 68940.65

Authors

Shaqra, A.M.,Schiffer, C.A. (deposition date: 2022-07-22, release date: 2023-03-29, Last modification date: 2023-10-25)

• Primary citation: Zvornicanin, S.N.,Shaqra, A.M.,Huang, Q.J.,Ornelas, E.,Moghe, M.,Knapp, M.,Moquin, S.,Dovala, D.,Schiffer, C.A.,Kurt Yilmaz, N.; Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.; Viruses, 15:-, 2023; PubMed: 36992489; DOI: 10.3390/v15030781

Experimental method

X-RAY DIFFRACTION (1.86 Å)