8DQF

Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide

8DQF の概要

• エントリーDOI: 10.2210/pdb8dqf/pdb
• 分子名称: Carbonic anhydrase, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, neisseria gonorrhoeae, acetazolamide, lyase
• 由来する生物種: Neisseria gonorrhoeae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 111550.56

構造登録者

Marapaka, A.K.,Das, C.,Flaherty, D.P.,Yadav, R. (登録日: 2022-07-19, 公開日: 2022-12-14, 最終更新日: 2023-10-25)

• 主引用文献: Marapaka, A.K.,Nocentini, A.,Youse, M.S.,An, W.,Holly, K.J.,Das, C.,Yadav, R.,Seleem, M.N.,Supuran, C.T.,Flaherty, D.P.; Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae alpha-Carbonic Anhydrase.; Acs Med.Chem.Lett., 14:103-109, 2023; PubMed: 36655133; DOI: 10.1021/acsmedchemlett.2c00471

実験手法

X-RAY DIFFRACTION (2.8 Å)