8DPH

Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin

Summary for 8DPH

• Entry DOI: 10.2210/pdb8dph/pdb
• EMDB information: 27635
• Descriptor: 5-hydroxytryptamine receptor 2C, G-alpha subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: gpcr, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 156822.97

Authors

Gumpper, R.H.,Fay, J.F.,Roth, B.L. (deposition date: 2022-07-15, release date: 2022-08-24, Last modification date: 2022-08-31)

• Primary citation: Gumpper, R.H.,Fay, J.F.,Roth, B.L.; Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.; Cell Rep, 40:111211-111211, 2022; PubMed: 35977511; DOI: 10.1016/j.celrep.2022.111211

Experimental method

ELECTRON MICROSCOPY (3.2 Å)