8DNW

Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2)

8DNW の概要

• エントリーDOI: 10.2210/pdb8dnw/pdb
• EMDBエントリー: 27582
• 分子名称: Protein transport protein Sec61 subunit gamma, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit alpha isoform 1 (3 entities in total)
• 機能のキーワード: translocon, inhibitor, protein translocation, protein transport, protein transport-inhibitor complex, protein transport/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 69942.22

構造登録者

Park, E.,Itskanov, S. (登録日: 2022-07-12, 公開日: 2023-05-24, 最終更新日: 2023-09-06)

• 主引用文献: Itskanov, S.,Wang, L.,Junne, T.,Sherriff, R.,Xiao, L.,Blanchard, N.,Shi, W.Q.,Forsyth, C.,Hoepfner, D.,Spiess, M.,Park, E.; A common mechanism of Sec61 translocon inhibition by small molecules.; Nat.Chem.Biol., 19:1063-1071, 2023; PubMed: 37169959; DOI: 10.1038/s41589-023-01337-y

実験手法

ELECTRON MICROSCOPY (3.4 Å)