8DKG

Structure of PYCR1 Thr171Met variant complexed with NADH

Summary for 8DKG

• Entry DOI: 10.2210/pdb8dkg/pdb
• Descriptor: Isoform 3 of Pyrroline-5-carboxylate reductase 1, mitochondrial, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 5
• Total formula weight: 174461.94

Authors

Meeks, K.R.,Tanner, J.J. (deposition date: 2022-07-05, release date: 2023-02-08, Last modification date: 2023-10-25)

• Primary citation: Daudu, O.I.,Meeks, K.R.,Zhang, L.,Seravalli, J.,Tanner, J.J.,Becker, D.F.; Functional Impact of a Cancer-Related Variant in Human Delta 1 -Pyrroline-5-Carboxylate Reductase 1.; Acs Omega, 8:3509-3519, 2023; PubMed: 36713721; DOI: 10.1021/acsomega.2c07788

Experimental method

X-RAY DIFFRACTION (1.85 Å)