8DHF

DHODH IN COMPLEX WITH LIGAND 11

8DHF の概要

• エントリーDOI: 10.2210/pdb8dhf/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
• 機能のキーワード: dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42572.17

構造登録者

Shaffer, P.L. (登録日: 2022-06-27, 公開日: 2022-08-17, 最終更新日: 2023-10-18)

• 主引用文献: Cisar, J.S.,Pietsch, C.,DeRatt, L.G.,Jacoby, E.,Kazmi, F.,Keohane, C.,Legenski, K.,Matico, R.,Shaffer, P.,Simonnet, Y.,Tanner, A.,Wang, C.Y.,Wang, W.,Attar, R.,Edwards, J.P.,Kuduk, S.D.; N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.; J.Med.Chem., 65:11241-11256, 2022; PubMed: 35925768; DOI: 10.1021/acs.jmedchem.2c00788

実験手法

X-RAY DIFFRACTION (1.78 Å)