8DGW

Crystal structure of HCoV-HKU1 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC95.108 isolated from a vaccinated COVID-19 convalescent

Summary for 8DGW

• Entry DOI: 10.2210/pdb8dgw/pdb
• Descriptor: Antibody CC95.108 Fab heavy chain, Antibody CC95.108 Fab light chain, Spike protein S2' (3 entities in total)
• Functional Keywords: broadly, neutralizing, antibody, pan-betacoronavirus, s2 stem helix, spike, sars-cov-2, mers-cov, hcov-hku1, sarbecovirus, cross-reactive, cross-neutralizing, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 196935.22

Authors

Liu, H.,Wilson, I.A. (deposition date: 2022-06-24, release date: 2023-01-25, Last modification date: 2023-10-25)

• Primary citation: Zhou, P.,Song, G.,Liu, H.,Yuan, M.,He, W.T.,Beutler, N.,Zhu, X.,Tse, L.V.,Martinez, D.R.,Schafer, A.,Anzanello, F.,Yong, P.,Peng, L.,Dueker, K.,Musharrafieh, R.,Callaghan, S.,Capozzola, T.,Limbo, O.,Parren, M.,Garcia, E.,Rawlings, S.A.,Smith, D.M.,Nemazee, D.,Jardine, J.G.,Safonova, Y.,Briney, B.,Rogers, T.F.,Wilson, I.A.,Baric, R.S.,Gralinski, L.E.,Burton, D.R.,Andrabi, R.; Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.; Immunity, 56:669-686.e7, 2023; PubMed: 36889306; DOI: 10.1016/j.immuni.2023.02.005

Experimental method

X-RAY DIFFRACTION (2.81 Å)