8DGV

Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC99.103 isolated from a vaccinated COVID-19 convalescent

8DGV の概要

• エントリーDOI: 10.2210/pdb8dgv/pdb
• 分子名称: Spike protein S2', Antibody CC99.103 Fab heavy chain, Antibody CC99.103 Fab light chain, ... (4 entities in total)
• 機能のキーワード: broadly neutralizing antibody, pan-betacoronavirus, s2 stem helix, spike, sars-cov-2, mers-cov, hcov-hku1, sarbecovirus, cross-reactive, cross-neutralizing, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 50281.34

構造登録者

Liu, H.,Wilson, I.A. (登録日: 2022-06-24, 公開日: 2023-01-25, 最終更新日: 2023-10-25)

• 主引用文献: Zhou, P.,Song, G.,Liu, H.,Yuan, M.,He, W.T.,Beutler, N.,Zhu, X.,Tse, L.V.,Martinez, D.R.,Schafer, A.,Anzanello, F.,Yong, P.,Peng, L.,Dueker, K.,Musharrafieh, R.,Callaghan, S.,Capozzola, T.,Limbo, O.,Parren, M.,Garcia, E.,Rawlings, S.A.,Smith, D.M.,Nemazee, D.,Jardine, J.G.,Safonova, Y.,Briney, B.,Rogers, T.F.,Wilson, I.A.,Baric, R.S.,Gralinski, L.E.,Burton, D.R.,Andrabi, R.; Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.; Immunity, 56:669-686.e7, 2023; PubMed: 36889306; DOI: 10.1016/j.immuni.2023.02.005

実験手法

X-RAY DIFFRACTION (2.3 Å)