8DGO

Growth Factor Receptor-Bound Protein 2 (Grb2) bound to phosphorylated PEAK3 (pY24) peptide

Summary for 8DGO

Entry DOI	10.2210/pdb8dgo/pdb
Descriptor	Growth factor receptor bound protein 2, Phosphorylated PEAK3 (pY24) peptide (3 entities in total)
Functional Keywords	sh2 domain, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	51672.77
Authors	Roy, M.J.,Hardy, J.M.,Lucet, I.S. (deposition date: 2022-06-24, release date: 2023-06-07, Last modification date: 2023-11-15)
Primary citation	Roy, M.J.,Surudoi, M.G.,Kropp, A.,Hou, J.,Dai, W.,Hardy, J.M.,Liang, L.Y.,Cotton, T.R.,Lechtenberg, B.C.,Dite, T.A.,Ma, X.,Daly, R.J.,Patel, O.,Lucet, I.S. Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14:3542-3542, 2023 Cited by PubMed: 37336884 DOI: 10.1038/s41467-023-38869-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation