8DFP

Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers

8DFP の概要

• エントリーDOI: 10.2210/pdb8dfp/pdb
• EMDBエントリー: 27410
• 分子名称: Isoform 2 of Mast/stem cell growth factor receptor Kit, Soluble KIT ligand, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: receptor tyrosine kinase, cell signaling, cancer, cryo-em, kit, stem cell factor, oncogenic mutant, extracellular domain, asymmetric interface, structural plasticity, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 253408.50

構造登録者

Bertoletti, N.,Krimmer, S.G.,Mi, W.,Schlessinger, J. (登録日: 2022-06-22, 公開日: 2023-03-29, 最終更新日: 2023-04-05)

• 主引用文献: Krimmer, S.G.,Bertoletti, N.,Suzuki, Y.,Katic, L.,Mohanty, J.,Shu, S.,Lee, S.,Lax, I.,Mi, W.,Schlessinger, J.; Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.; Proc.Natl.Acad.Sci.USA, 120:e2300054120-e2300054120, 2023; PubMed: 36943885; DOI: 10.1073/pnas.2300054120

実験手法

ELECTRON MICROSCOPY (3.17 Å)