8DDI
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166N Mutant
Summary for 8DDI
Entry DOI | 10.2210/pdb8ddi/pdb |
Descriptor | 3C-like proteinase nsp5 (2 entities in total) |
Functional Keywords | protease, sars-cov-2, mpro, mutation, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 1 |
Total formula weight | 33810.54 |
Authors | Lewandowski, E.M.,Jacobs, L.M.C.,Chen, Y. (deposition date: 2022-06-18, release date: 2022-08-31, Last modification date: 2023-10-25) |
Primary citation | Ou, J.,Lewandowski, E.M.,Hu, Y.,Lipinski, A.A.,Aljasser, A.,Colon-Ascanio, M.,Morgan, R.T.,Jacobs, L.M.C.,Zhang, X.,Bikowitz, M.J.,Langlais, P.R.,Tan, H.,Wang, J.,Chen, Y.,Choy, J.S. A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations. Plos Pathog., 19:e1011592-e1011592, 2023 Cited by PubMed: 37651467DOI: 10.1371/journal.ppat.1011592 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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