8DD8
PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG
Summary for 8DD8
Entry DOI | 10.2210/pdb8dd8/pdb |
EMDB information | 27336 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total) |
Functional Keywords | phosphoinositide 3-kinase (pi3k), activation, inhibition, nanobody, conformational changes, structural protein, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 211445.78 |
Authors | Hart, J.R.,Liu, X.,Pan, C.,Liang, A.,Ueno, L.,Xu, Y.,Quezada, A.,Zou, X.,Yang, S.,Zhou, Q.,Schoonooghe, S.,Hassanzadeh-Ghassabeh, G.,Xia, T.,Shui, W.,Yang, D.,Vogt, P.K.,Wang, M.-W. (deposition date: 2022-06-17, release date: 2022-09-21, Last modification date: 2024-06-12) |
Primary citation | Hart, J.R.,Liu, X.,Pan, C.,Liang, A.,Ueno, L.,Xu, Y.,Quezada, A.,Zou, X.,Yang, S.,Zhou, Q.,Schoonooghe, S.,Hassanzadeh-Ghassabeh, G.,Xia, T.,Shui, W.,Yang, D.,Vogt, P.K.,Wang, M.W. Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119:e2210769119-e2210769119, 2022 Cited by PubMed: 36095215DOI: 10.1073/pnas.2210769119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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