8DAI
E. coli DHFR complex with NADP+ and 10-methylfolate
Summary for 8DAI
| Entry DOI | 10.2210/pdb8dai/pdb |
| Descriptor | Dihydrofolate reductase, methopterin, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | dihydrofolate reductase, oxidoreductase |
| Biological source | Escherichia coli K-12 |
| Total number of polymer chains | 1 |
| Total formula weight | 19469.92 |
| Authors | Greisman, J.B.,Brookner, D.E.,Hekstra, D.R. (deposition date: 2022-06-13, release date: 2023-06-21, Last modification date: 2024-07-24) |
| Primary citation | Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Klureza, M.A.,Sheehan, C.J.,Kim, I.S.,Henning, R.W.,Russi, S.,Hekstra, D.R. Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121:e2313192121-e2313192121, 2024 Cited by PubMed: 38386706DOI: 10.1073/pnas.2313192121 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.14 Å) |
Structure validation
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