8D9C
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 10
Summary for 8D9C
Entry DOI | 10.2210/pdb8d9c/pdb |
Descriptor | Hdac6 protein, 2,3,4,5,6-pentafluoro-N-hydroxybenzamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 81312.35 |
Authors | Watson, P.R.,Christianson, D.W. (deposition date: 2022-06-09, release date: 2022-09-28, Last modification date: 2023-10-18) |
Primary citation | Watson, P.R.,Bai, P.,Wang, C.,Cragin, A.D.,Hooker, J.M.,Christianson, D.W. Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61:1945-1954, 2022 Cited by PubMed: 36073962DOI: 10.1021/acs.biochem.2c00332 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
Download full validation report