8D98

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 5

Summary for 8D98

Entry DOI	10.2210/pdb8d98/pdb
Descriptor	Hdac6 protein, 3,5-difluoro-N-hydroxybenzamide, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	2
Total formula weight	81204.41
Authors	Watson, P.R.,Christianson, D.W. (deposition date: 2022-06-09, release date: 2022-09-28, Last modification date: 2023-10-18)
Primary citation	Watson, P.R.,Bai, P.,Wang, C.,Cragin, A.D.,Hooker, J.M.,Christianson, D.W. Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61:1945-1954, 2022 Cited by PubMed: 36073962 DOI: 10.1021/acs.biochem.2c00332 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation