8D98

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 5

8D98 の概要

• エントリーDOI: 10.2210/pdb8d98/pdb
• 分子名称: Hdac6 protein, 3,5-difluoro-N-hydroxybenzamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81204.41

構造登録者

Watson, P.R.,Christianson, D.W. (登録日: 2022-06-09, 公開日: 2022-09-28, 最終更新日: 2023-10-18)

• 主引用文献: Watson, P.R.,Bai, P.,Wang, C.,Cragin, A.D.,Hooker, J.M.,Christianson, D.W.; Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6.; Biochemistry, 61:1945-1954, 2022; PubMed: 36073962; DOI: 10.1021/acs.biochem.2c00332

実験手法

X-RAY DIFFRACTION (1.66 Å)