8D7O
Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide
Summary for 8D7O
Entry DOI | 10.2210/pdb8d7o/pdb |
Descriptor | Casein kinase I isoform delta, Period circadian protein homolog 2 peptide (3 entities in total) |
Functional Keywords | transferase, circadian clock protein, complex, kinase, transferase-circadian clock protein complex, transferase/circadian clock protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 73754.01 |
Authors | Philpott, J.M.,Freeberg, A.M.,Tripathi, S.M.,Partch, C.L. (deposition date: 2022-06-07, release date: 2023-05-17, Last modification date: 2023-10-25) |
Primary citation | Philpott, J.M.,Freeberg, A.M.,Park, J.,Lee, K.,Ricci, C.G.,Hunt, S.R.,Narasimamurthy, R.,Segal, D.H.,Robles, R.,Cai, Y.,Tripathi, S.,McCammon, J.A.,Virshup, D.M.,Chiu, J.C.,Lee, C.,Partch, C.L. PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83:1677-1692.e8, 2023 Cited by PubMed: 37207626DOI: 10.1016/j.molcel.2023.04.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report