8D56

One RBD-up state of SARS-CoV-2 BA.2 variant spike protein

8D56 の概要

• エントリーDOI: 10.2210/pdb8d56/pdb
• EMDBエントリー: 27206
• 分子名称: Spike glycoprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 454798.83

構造登録者

Zhang, J.,Tang, W.C.,Gao, H.L.,Shi, W.,Peng, H.Q.,Volloch, S.R.,Xiao, T.S.,Chen, B. (登録日: 2022-06-04, 公開日: 2023-06-07, 最終更新日: 2024-10-23)

主引用文献

Zhang, J.,Tang, W.,Gao, H.,Lavine, C.L.,Shi, W.,Peng, H.,Zhu, H.,Anand, K.,Kosikova, M.,Kwon, H.J.,Tong, P.,Gautam, A.,Rits-Volloch, S.,Wang, S.,Mayer, M.L.,Wesemann, D.R.,Seaman, M.S.,Lu, J.,Xiao, T.,Xie, H.,Chen, B.
Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein.
Nat.Struct.Mol.Biol., 30:980-990, 2023

PubMed Abstract: The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many countries. Here, we have characterized structural, functional and antigenic properties of the full-length BA.2 spike (S) protein and compared replication of the authentic virus in cell culture and an animal model with previously prevalent variants. BA.2 S can fuse membranes slightly more efficiently than Omicron BA.1, but still less efficiently than other previous variants. Both BA.1 and BA.2 viruses replicated substantially faster in animal lungs than the early G614 (B.1) strain in the absence of pre-existing immunity, possibly explaining the increased transmissibility despite their functionally compromised spikes. As in BA.1, mutations in the BA.2 S remodel its antigenic surfaces, leading to strong resistance to neutralizing antibodies. These results suggest that both immune evasion and replicative advantage may contribute to the heightened transmissibility of the Omicron subvariants.

PubMed: 37430064
DOI: 10.1038/s41594-023-01023-6

実験手法

ELECTRON MICROSCOPY (3 Å)