8D4N
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166Q Mutant
Summary for 8D4N
Entry DOI | 10.2210/pdb8d4n/pdb |
Related | 8D4J 8D4K 8D4L 8D4M |
Descriptor | 3C-like proteinase nsp5 (2 entities in total) |
Functional Keywords | protease, sars-cov-2, mpro, mutation, viral protein, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 67649.12 |
Authors | Lewandowski, E.M.,Hu, Y.,Tan, H.,Wang, J.,Chen, Y. (deposition date: 2022-06-02, release date: 2022-07-13, Last modification date: 2023-10-18) |
Primary citation | Hu, Y.,Lewandowski, E.M.,Tan, H.,Zhang, X.,Morgan, R.T.,Zhang, X.,Jacobs, L.M.C.,Butler, S.G.,Gongora, M.V.,Choy, J.,Deng, X.,Chen, Y.,Wang, J. Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022 Cited by PubMed: 36119652DOI: 10.1101/2022.06.28.497978 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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