8D3G

Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with 6-chloroquinolin-4-amine

Summary for 8D3G

Entry DOI	10.2210/pdb8d3g/pdb
Descriptor	Apoptosis-inducing factor 1, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, 6-chloroquinolin-4-amine, ... (5 entities in total)
Functional Keywords	oxidoreductase, mitochondrial import, oxidative phosphorylation, saxs
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	120733.27
Authors	Brosey, C.A.,Tainer, J.A. (deposition date: 2022-06-01, release date: 2023-11-08, Last modification date: 2024-05-29)
Primary citation	Brosey, C.A.,Link, T.M.,Shen, R.,Moiani, D.,Burnett, K.,Hura, G.L.,Jones, D.E.,Tainer, J.A. Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nat.Chem.Biol., 2024 Cited by PubMed: 38671223 DOI: 10.1038/s41589-024-01609-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation