8CZZ
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074
Summary for 8CZZ
Entry DOI | 10.2210/pdb8czz/pdb |
EMDB information | 27103 |
Descriptor | CRF01_AE T/F100 HIV-1 gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total) |
Functional Keywords | t/f100 sosip, clade a/e hiv-1, 8anc195, 10-1074, bms-626529, temsavir, lmhs mutant., viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 18 |
Total formula weight | 537669.84 |
Authors | Chen, Y.,Pozharski, E.,Tolbert, W.,Pazgier, M. (deposition date: 2022-05-25, release date: 2023-05-31, Last modification date: 2023-11-08) |
Primary citation | Prevost, J.,Chen, Y.,Zhou, F.,Tolbert, W.D.,Gasser, R.,Medjahed, H.,Nayrac, M.,Nguyen, D.N.,Gottumukkala, S.,Hessell, A.J.,Rao, V.B.,Pozharski, E.,Huang, R.K.,Matthies, D.,Finzi, A.,Pazgier, M. Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14:6710-6710, 2023 Cited by PubMed: 37872202DOI: 10.1038/s41467-023-42500-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.14 Å) |
Structure validation
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