8CXZ

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-(3-Phenylpropyl)adenosine (Compound 14)

8CXZ の概要

• エントリーDOI: 10.2210/pdb8cxz/pdb
• 分子名称: Site-specific DNA-methyltransferase (adenine-specific), DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Clostridioides difficile; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 233849.41

構造登録者

Zhou, J.,Horton, J.R.,Cheng, X. (登録日: 2022-05-22, 公開日: 2023-01-11, 最終更新日: 2024-05-22)

• 主引用文献: Zhou, J.,Horton, J.R.,Menna, M.,Fiorentino, F.,Ren, R.,Yu, D.,Hajian, T.,Vedadi, M.,Mazzoccanti, G.,Ciogli, A.,Weinhold, E.,Huben, M.,Blumenthal, R.M.,Zhang, X.,Mai, A.,Rotili, D.,Cheng, X.; Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.; J.Med.Chem., 66:934-950, 2023; PubMed: 36581322; DOI: 10.1021/acs.jmedchem.2c01789

実験手法

X-RAY DIFFRACTION (2.35 Å)