8CQA

Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide

Summary for 8CQA

• Entry DOI: 10.2210/pdb8cqa/pdb
• Descriptor: Dihydrofolate reductase, ~{N}-[4-[2,6-bis(azanyl)-5-(2-cyclopropylethyl)pyrimidin-4-yl]phenyl]ethanamide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• Functional Keywords: dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 38132.94

Authors

Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. (deposition date: 2023-03-04, release date: 2024-03-13)

• Primary citation: Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G.; Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently); To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)