8CQA

Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide

8CQA の概要

• エントリーDOI: 10.2210/pdb8cqa/pdb
• 分子名称: Dihydrofolate reductase, ~{N}-[4-[2,6-bis(azanyl)-5-(2-cyclopropylethyl)pyrimidin-4-yl]phenyl]ethanamide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38132.94

構造登録者

Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. (登録日: 2023-03-04, 公開日: 2024-03-13)

• 主引用文献: Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G.; Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently); To Be Published,

実験手法

X-RAY DIFFRACTION (2 Å)