8CPJ

Crystal structure of PPAR gamma (PPARG) in an inactive form

Summary for 8CPJ

Entry DOI	10.2210/pdb8cpj/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	pparg, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31854.00
Authors	Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-03-02, release date: 2023-07-12, Last modification date: 2023-07-19)
Primary citation	Arifi, S.,Marschner, J.A.,Pollinger, J.,Isigkeit, L.,Heitel, P.,Kaiser, A.,Obeser, L.,Hofner, G.,Proschak, E.,Knapp, S.,Chaikuad, A.,Heering, J.,Merk, D. Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145:14802-14810, 2023 Cited by PubMed: 37385602 DOI: 10.1021/jacs.3c03417 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation