8CPH
Crystal structure of PPAR gamma (PPARG) in complex with WY-14643 (inactive form)
Summary for 8CPH
| Entry DOI | 10.2210/pdb8cph/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID (3 entities in total) |
| Functional Keywords | pparg, allosteric inhibitor, orthosteric inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 63983.18 |
| Authors | Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-03-02, release date: 2023-07-12, Last modification date: 2023-07-19) |
| Primary citation | Arifi, S.,Marschner, J.A.,Pollinger, J.,Isigkeit, L.,Heitel, P.,Kaiser, A.,Obeser, L.,Hofner, G.,Proschak, E.,Knapp, S.,Chaikuad, A.,Heering, J.,Merk, D. Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145:14802-14810, 2023 Cited by PubMed: 37385602DOI: 10.1021/jacs.3c03417 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report
