8CPH

Crystal structure of PPAR gamma (PPARG) in complex with WY-14643 (inactive form)

8CPH の概要

• エントリーDOI: 10.2210/pdb8cph/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID (3 entities in total)
• 機能のキーワード: pparg, allosteric inhibitor, orthosteric inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63983.18

構造登録者

Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2023-03-02, 公開日: 2023-07-12, 最終更新日: 2023-07-19)

• 主引用文献: Arifi, S.,Marschner, J.A.,Pollinger, J.,Isigkeit, L.,Heitel, P.,Kaiser, A.,Obeser, L.,Hofner, G.,Proschak, E.,Knapp, S.,Chaikuad, A.,Heering, J.,Merk, D.; Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation.; J.Am.Chem.Soc., 145:14802-14810, 2023; PubMed: 37385602; DOI: 10.1021/jacs.3c03417

実験手法

X-RAY DIFFRACTION (2.4 Å)