8CP0
Structure of the catalytic domain of P. vivax Sub1 (trigonal crystal form)
Summary for 8CP0
| Entry DOI | 10.2210/pdb8cp0/pdb |
| Related | 8coz |
| Descriptor | subtilisin, CALCIUM ION (2 entities in total) |
| Functional Keywords | plasmodium, serine protease, drug target, malaria, hydrolase |
| Biological source | Plasmodium vivax (malaria parasite P. vivax) |
| Total number of polymer chains | 1 |
| Total formula weight | 43714.03 |
| Authors | Martinez, M.,Bouillon, A.,Batista, F.,Alzari, P.M.,Barale, J.C.,Haouz, A. (deposition date: 2023-03-01, release date: 2023-07-19, Last modification date: 2023-11-22) |
| Primary citation | Martinez, M.,Batista, F.A.,Maurel, M.,Bouillon, A.,Ortega Varga, L.,Wehenkel, A.M.,Le Chevalier-Sontag, L.,Blondel, A.,Haouz, A.,Hernandez, J.F.,Alzari, P.M.,Barale, J.C. 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor. Acta Crystallogr D Struct Biol, 79:721-734, 2023 Cited by PubMed: 37428845DOI: 10.1107/S2059798323004710 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.251 Å) |
Structure validation
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