8COY

Structure of the catalytic domain of P. vivax Sub1 (triclinic crystal form) in complex with inhibitor

8COY の概要

• エントリーDOI: 10.2210/pdb8coy/pdb
• 分子名称: subtilisin, peptido-mimetic inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: plasmodium, serine protease, drug target, malaria, pseudo-peptide inhibitor, hydrolase
• 由来する生物種: Plasmodium vivax (malaria parasite P. vivax); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78264.11

構造登録者

Martinez, M.,Bouillon, A.,Batista, F.,Alzari, P.M.,Barale, J.C.,Haouz, A. (登録日: 2023-03-01, 公開日: 2023-07-19, 最終更新日: 2023-11-22)

• 主引用文献: Martinez, M.,Batista, F.A.,Maurel, M.,Bouillon, A.,Ortega Varga, L.,Wehenkel, A.M.,Le Chevalier-Sontag, L.,Blondel, A.,Haouz, A.,Hernandez, J.F.,Alzari, P.M.,Barale, J.C.; 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.; Acta Crystallogr D Struct Biol, 79:721-734, 2023; PubMed: 37428845; DOI: 10.1107/S2059798323004710

実験手法

X-RAY DIFFRACTION (1.507 Å)