8COP

Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide

Summary for 8COP

• Entry DOI: 10.2210/pdb8cop/pdb
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: mycobacterium tuberculosis dihydrofolate reductase, biosynthetic protein
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 38367.01

Authors

Kirkman, T.J.,Dias, M.V.B. (deposition date: 2023-02-28, release date: 2024-03-06)

• Primary citation: Kirkmna, T.J.,Dias, M.V.B.,Coyne, A.; Expansion of a series of pyrimidine derivatives utilising fragment-based merging showcasing anleads to increased affinity with to Mycobacterium tuberculosis dihydrofolate reductase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)