8COP

Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide

8COP の概要

• エントリーDOI: 10.2210/pdb8cop/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: mycobacterium tuberculosis dihydrofolate reductase, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38367.01

構造登録者

Kirkman, T.J.,Dias, M.V.B. (登録日: 2023-02-28, 公開日: 2024-03-06)

• 主引用文献: Kirkmna, T.J.,Dias, M.V.B.,Coyne, A.; Expansion of a series of pyrimidine derivatives utilising fragment-based merging showcasing anleads to increased affinity with to Mycobacterium tuberculosis dihydrofolate reductase; To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)