8COO

Solution structure of Zipcode binding protein 1 (ZBP1) KH3(DD)KH4 domains in complex with N6-Methyladenosine containing RNA

8COO の概要

• エントリーDOI: 10.2210/pdb8coo/pdb
• 関連するPDBエントリー: 2N8M
• NMR情報: BMRB: 34660
• 分子名称: Insulin-like growth factor 2 mRNA-binding protein 1, RNA_(5'-R(*(UP*CP*GP*GP*(6MZ)P*CP*U)-3') (2 entities in total)
• 機能のキーワード: protein-rna interactions; nmr; binding mechanism; neuronal mrna granules; neuronal development; mrna local translation; zbp1; imp1; m6a-n6-methyladenosine rna;, rna binding protein
• 由来する生物種: Gallus gallus (chicken); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22824.88

構造登録者

Nicastro, G.,Abis, G.,Taylor, I.A.,Ramos, A. (登録日: 2023-02-28, 公開日: 2024-02-07)

• 主引用文献: Nicastro, G.,Abis, G.,Klein, P.,Esteban-Serna, S.,Gallagher, C.,Chaves-Arquero, B.,Cai, Y.,Figueiredo, A.M.,Martin, S.R.,Patani, R.,Taylor, I.A.,Ramos, A.; Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers.; Nucleic Acids Res., 51:8774-8786, 2023; PubMed: 37377445; DOI: 10.1093/nar/gkad534

実験手法

SOLUTION NMR