8CNG

Pa.FabF-C164Q in complex with ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide

8CNG の概要

• エントリーDOI: 10.2210/pdb8cng/pdb
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, protein-ligand complex, fabf, transferase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87331.78

構造登録者

Georgiou, C.,Brenk, R. (登録日: 2023-02-22, 公開日: 2024-01-10)

• 主引用文献: Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R.; New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-cwk25

実験手法

X-RAY DIFFRACTION (2.1 Å)