8CNA

Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA

Summary for 8CNA

• Entry DOI: 10.2210/pdb8cna/pdb
• Descriptor: histone acetyltransferase, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate (3 entities in total)
• Functional Keywords: histone acetyltransferase, transferase
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 1
• Total formula weight: 76254.77

Authors

Mechaly, A.E.,Zhang, W.,Haouz, A.,Green, M.,Rodrigues-Lima, F. (deposition date: 2023-02-22, release date: 2024-03-06)

• Primary citation: Mechaly, A.E.,Zhang, W.,Haouz, A.,Green, M.,Rodrigues-Lima, F.; Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.463 Å)