8CNA

Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA

8CNA の概要

• エントリーDOI: 10.2210/pdb8cna/pdb
• 分子名称: histone acetyltransferase, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate (3 entities in total)
• 機能のキーワード: histone acetyltransferase, transferase
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76254.77

構造登録者

Mechaly, A.E.,Zhang, W.,Haouz, A.,Green, M.,Rodrigues-Lima, F. (登録日: 2023-02-22, 公開日: 2024-03-06)

• 主引用文献: Mechaly, A.E.,Zhang, W.,Haouz, A.,Green, M.,Rodrigues-Lima, F.; Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA; To Be Published,

実験手法

X-RAY DIFFRACTION (2.463 Å)