8CLG

Epothilone A and Colchicine bound to tubulin (T2R-TTL) complex

8CLG の概要

• エントリーDOI: 10.2210/pdb8clg/pdb
• 分子名称: Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: drug-tubulin-complex cell cycle inhibition, cell cycle
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 253950.65

構造登録者

Wranik, M.,Bertrand, Q.,Kepa, M.W.,Weinert, T.,Steinmetz, M.,Standfuss, J. (登録日: 2023-02-16, 公開日: 2023-12-13)

• 主引用文献: Wranik, M.,Kepa, M.W.,Beale, E.V.,James, D.,Bertrand, Q.,Weinert, T.,Furrer, A.,Glover, H.,Gashi, D.,Carrillo, M.,Kondo, Y.,Stipp, R.T.,Khusainov, G.,Nass, K.,Ozerov, D.,Cirelli, C.,Johnson, P.J.M.,Dworkowski, F.,Beale, J.H.,Stubbs, S.,Zamofing, T.,Schneider, M.,Krauskopf, K.,Gao, L.,Thorn-Seshold, O.,Bostedt, C.,Bacellar, C.,Steinmetz, M.O.,Milne, C.,Standfuss, J.; A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.; Nat Commun, 14:7956-7956, 2023; PubMed: 38042952; DOI: 10.1038/s41467-023-43523-5

実験手法

X-RAY DIFFRACTION (2.8 Å)