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8CKF

Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand

Summary for 8CKF
Entry DOI10.2210/pdb8ckf/pdb
DescriptorBromodomain-containing protein 4, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{S})-oxidanyl(pyridin-3-yl)methyl]phenol, ... (4 entities in total)
Functional Keywordsbromodomain, ligand, epigenetics, reader domain, transcription regulation, gene regulation
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight18153.68
Authors
Thomas, A.M.,McDonough, M.A.,Schiedel, M.,Conway, S.J. (deposition date: 2023-02-15, release date: 2023-08-02, Last modification date: 2023-11-29)
Primary citationThomas, A.M.,Serafini, M.,Grant, E.K.,Coombs, E.A.J.,Bluck, J.P.,Schiedel, M.,McDonough, M.A.,Reynolds, J.K.,Lee, B.,Platt, M.,Sharlandjieva, V.,Biggin, P.C.,Duarte, F.,Milne, T.A.,Bush, J.T.,Conway, S.J.
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.
Acs Chem.Biol., 18:2405-2417, 2023
Cited by
PubMed: 37874862
DOI: 10.1021/acschembio.3c00437
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.88 Å)
Structure validation

221051

数据于2024-06-12公开中

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