8CKF

Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand

8CKF の概要

• エントリーDOI: 10.2210/pdb8ckf/pdb
• 分子名称: Bromodomain-containing protein 4, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{S})-oxidanyl(pyridin-3-yl)methyl]phenol, ... (4 entities in total)
• 機能のキーワード: bromodomain, ligand, epigenetics, reader domain, transcription regulation, gene regulation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18153.68

構造登録者

Thomas, A.M.,McDonough, M.A.,Schiedel, M.,Conway, S.J. (登録日: 2023-02-15, 公開日: 2023-08-02, 最終更新日: 2023-11-29)

• 主引用文献: Thomas, A.M.,Serafini, M.,Grant, E.K.,Coombs, E.A.J.,Bluck, J.P.,Schiedel, M.,McDonough, M.A.,Reynolds, J.K.,Lee, B.,Platt, M.,Sharlandjieva, V.,Biggin, P.C.,Duarte, F.,Milne, T.A.,Bush, J.T.,Conway, S.J.; Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.; Acs Chem.Biol., 18:2405-2417, 2023; PubMed: 37874862; DOI: 10.1021/acschembio.3c00437

実験手法

X-RAY DIFFRACTION (1.88 Å)