8CKC

Vitamin D receptor complex with 25-amine derivative of 1,25D3

Summary for 8CKC

• Entry DOI: 10.2210/pdb8ckc/pdb
• Descriptor: Vitamin D3 receptor A, Nuclear receptor coactivator 1, ACETATE ION, ... (5 entities in total)
• Functional Keywords: complex, agonist, nuclear receptor, transcription
• Biological source: Danio rerio (zebrafish); More
• Total number of polymer chains: 2
• Total formula weight: 36311.44

Authors

Rochel, N. (deposition date: 2023-02-15, release date: 2023-04-26, Last modification date: 2024-06-19)

Primary citation

Gomez-Bouzo, U.,Belorusova, A.Y.,Rivadulla, M.L.,Santalla, H.,Verlinden, L.,Verstuyf, A.,Ferronato, M.J.,Curino, A.C.,Facchinetti, M.M.,Fall, Y.,Gomez, G.,Rochel, N.
Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs.
Bioorg.Chem., 136:106528-106528, 2023

PubMed Abstract: Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediate biological effects similar to 1,25-dihydroxyvitamin D, the 25-amino derivative being the most potent one while being less calcemic than 1,25-dihydroxyvitamin D. The in vivo properties of the compounds make them of potential therapeutic value.

PubMed: 37054528
DOI: 10.1016/j.bioorg.2023.106528

Experimental method

X-RAY DIFFRACTION (2.1 Å)