8CJ2

Urea-based foldamer inhibitor c3u_5 chimera in complex with ASF1 histone chaperone

8CJ2 の概要

• エントリーDOI: 10.2210/pdb8cj2/pdb
• 分子名称: Histone chaperone ASF1A, c3u_5 chimera inhibitor of histone chaperone ASF1, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: inhibitor, asf1, histone, protein-protein interaction, chaperone
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 78171.68

構造登録者

Perrin, M.E.,Li, B.,Mbianda, J.,Ropars, V.,Legrand, P.,Douat, C.,Ochsenbein, F.,Guichard, G. (登録日: 2023-02-11, 公開日: 2023-07-05, 最終更新日: 2024-07-10)

主引用文献

Perrin, M.E.,Li, B.,Mbianda, J.,Bakail, M.,Andre, C.,Moal, G.,Legrand, P.,Ropars, V.,Douat, C.,Ochsenbein, F.,Guichard, G.
Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.
Chem.Commun.(Camb.), 59:8696-8699, 2023

PubMed Abstract: In the search for foldamer inhibitors of the histone chaperone ASF1, we explored the possibility of substituting four α-residues (≈one helix turn) by 3-urea segments and scanned the sequence of a short α-helical peptide known to bind ASF1. By analysing the impact of the different foldamer replacements within the peptide chain, we uncovered new binding modes of the peptide-urea chimeras to ASF1.

PubMed: 37347155
DOI: 10.1039/d3cc01891a

実験手法

X-RAY DIFFRACTION (2.127 Å)