8CIY

DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Cyclohexyl-Griselimycin.

Summary for 8CIY

Entry DOI	10.2210/pdb8ciy/pdb
Related PRD ID	PRD_002466
Descriptor	Beta sliding clamp, Cyclohexyl-Griselimycin, CALCIUM ION, ... (8 entities in total)
Functional Keywords	dnan, sliding clamp, dna-polymerase beta subunit, antibiotic, natural product, anti-tuberculosis, transferase
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	42727.61
Authors	Fu, C.,Liu, Y.,Walt, C.,Bader, C.,Rasheed, S.,Lukat, P.,Neuber, M.,Blankenfeldt, W.,Kalinina, O.,Mueller, R. (deposition date: 2023-02-11, release date: 2023-11-29, Last modification date: 2024-02-07)
Primary citation	Fu, C.,Liu, Y.,Walt, C.,Rasheed, S.,Bader, C.D.,Lukat, P.,Neuber, M.,Haeckl, F.P.J.,Blankenfeldt, W.,Kalinina, O.V.,Muller, R. Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nat Commun, 15:791-791, 2024 Cited by PubMed: 38278788 DOI: 10.1038/s41467-024-44953-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation