8CHW

Crystal structure of human PURA (fragment Pro216-Lys280, PUR repeat III)

Summary for 8CHW

Entry DOI	10.2210/pdb8chw/pdb
Descriptor	Transcriptional activator protein Pur-alpha, 1,2-ETHANEDIOL, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	rna/dna binding, pur repeat, pc4-like fold, rna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	16423.36
Authors	Janowski, R.,Niessing, D. (deposition date: 2023-02-08, release date: 2024-02-21, Last modification date: 2024-05-08)
Primary citation	Proske, M.,Janowski, R.,Bacher, S.,Kang, H.S.,Monecke, T.,Koehler, T.,Hutten, S.,Tretter, J.,Crois, A.,Molitor, L.,Varela-Rial, A.,Fino, R.,Donati, E.,De Fabritiis, G.,Dormann, D.,Sattler, M.,Niessing, D. PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. Elife, 13:-, 2024 Cited by PubMed: 38655849 DOI: 10.7554/eLife.93561 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation