8CH8

Crystal structure of the human PXR ligand-binding domain in complex with liranaftate

Summary for 8CH8

• Entry DOI: 10.2210/pdb8ch8/pdb
• Descriptor: Nuclear receptor subfamily 1 group I member 2, ~{O}-(5,6,7,8-tetrahydronaphthalen-2-yl) ~{N}-(6-methoxypyridin-2-yl)-~{N}-methyl-carbamothioate (3 entities in total)
• Functional Keywords: nuclear receptor, pregnane x receptor, nuclear protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37075.89

Authors

Carivenc, C.,Derosa, Q.,Grimaldi, M.,Boulahtouf, A.,Balaguer, P.,Bourguet, W. (deposition date: 2023-02-07, release date: 2024-02-21)

• Primary citation: Carivenc, C.,Derosa, Q.,Grimaldi, M.,Boulahtouf, A.,Balaguer, P.,Bourguet, W.; Crystal structure of the human PXR ligand-binding domain in complex with liranaftate; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)