8CGW

Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor

Summary for 8CGW

Entry DOI	10.2210/pdb8cgw/pdb
Descriptor	Leucyl-cystinyl aminopeptidase, pregnancy serum form, 1,2-ETHANEDIOL, GLYCINE, ... (12 entities in total)
Functional Keywords	insulin-regulated aminopeptidase, allosteric inhibitor, benzopyran scaffold, antigen presentation, hfi-419, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	211446.03
Authors	Mpakali, A.,Stratikos, E.,Giastas, P. (deposition date: 2023-02-06, release date: 2024-01-31, Last modification date: 2024-02-14)
Primary citation	Mpakali, A.,Barla, I.,Lu, L.,Ramesh, K.M.,Thomaidis, N.,Stern, L.J.,Giastas, P.,Stratikos, E. Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J.Mol.Biol., 436:168449-168449, 2024 Cited by PubMed: 38244767 DOI: 10.1016/j.jmb.2024.168449 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.03 Å)

Structure validation