8CGW

Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor

8CGW の概要

• エントリーDOI: 10.2210/pdb8cgw/pdb
• 分子名称: Leucyl-cystinyl aminopeptidase, pregnancy serum form, 1,2-ETHANEDIOL, GLYCINE, ... (12 entities in total)
• 機能のキーワード: insulin-regulated aminopeptidase, allosteric inhibitor, benzopyran scaffold, antigen presentation, hfi-419, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 211446.03

構造登録者

Mpakali, A.,Stratikos, E.,Giastas, P. (登録日: 2023-02-06, 公開日: 2024-01-31, 最終更新日: 2024-02-14)

• 主引用文献: Mpakali, A.,Barla, I.,Lu, L.,Ramesh, K.M.,Thomaidis, N.,Stern, L.J.,Giastas, P.,Stratikos, E.; Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.; J.Mol.Biol., 436:168449-168449, 2024; PubMed: 38244767; DOI: 10.1016/j.jmb.2024.168449

実験手法

X-RAY DIFFRACTION (3.03 Å)