8CGO

Structure of human butyrylcholinesterase in complex with N-{[2-(benzyloxy)-3-methoxyphenyl]methyl}-N-[3-(2-fluorophenyl)propyl]cyclobutanamine

Summary for 8CGO

Entry DOI	10.2210/pdb8cgo/pdb
Descriptor	Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	butyrylcholinesterase, inhibitor, complex., hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	63446.12
Authors	Brazzolotto, X.,Pidany, F.,Korabecny, J.,Cahlikova, L.,Nachon, F. (deposition date: 2023-02-06, release date: 2023-06-14)
Primary citation	Pidany, F.,Kroustkova, J.,Al Mamun, A.,Suchankova, D.,Brazzolotto, X.,Nachon, F.,Chantegreil, F.,Dolezal, R.,Pulkrabkova, L.,Muckova, L.,Hrabinova, M.,Finger, V.,Kufa, M.,Soukup, O.,Jun, D.,Jenco, J.,Kunes, J.,Novakova, L.,Korabecny, J.,Cahlikova, L. Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation. Eur.J.Med.Chem., 252:115301-115301, 2023 Cited by PubMed: 36996715 DOI: 10.1016/j.ejmech.2023.115301 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation