8CGO

Structure of human butyrylcholinesterase in complex with N-{[2-(benzyloxy)-3-methoxyphenyl]methyl}-N-[3-(2-fluorophenyl)propyl]cyclobutanamine

8CGO の概要

• エントリーDOI: 10.2210/pdb8cgo/pdb
• 分子名称: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: butyrylcholinesterase, inhibitor, complex., hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63446.12

構造登録者

Brazzolotto, X.,Pidany, F.,Korabecny, J.,Cahlikova, L.,Nachon, F. (登録日: 2023-02-06, 公開日: 2023-06-14)

• 主引用文献: Pidany, F.,Kroustkova, J.,Al Mamun, A.,Suchankova, D.,Brazzolotto, X.,Nachon, F.,Chantegreil, F.,Dolezal, R.,Pulkrabkova, L.,Muckova, L.,Hrabinova, M.,Finger, V.,Kufa, M.,Soukup, O.,Jun, D.,Jenco, J.,Kunes, J.,Novakova, L.,Korabecny, J.,Cahlikova, L.; Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation.; Eur.J.Med.Chem., 252:115301-115301, 2023; PubMed: 36996715; DOI: 10.1016/j.ejmech.2023.115301

実験手法

X-RAY DIFFRACTION (2.65 Å)