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8CEQ

Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO427

Summary for 8CEQ
Entry DOI10.2210/pdb8ceq/pdb
DescriptorCap-specific mRNA (nucleoside-2'-O-)-methyltransferase, (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid (3 entities in total)
Functional Keywordsviral, methyltransferase, vp39, monkeypox, mpox, capping, enzyme, inhibitor, viral protein
Biological sourceMonkeypox virus
Total number of polymer chains2
Total formula weight72866.06
Authors
Klima, M.,Silhan, J.,Boura, E. (deposition date: 2023-02-02, release date: 2023-04-05, Last modification date: 2023-05-03)
Primary citationSilhan, J.,Klima, M.,Otava, T.,Skvara, P.,Chalupska, D.,Chalupsky, K.,Kozic, J.,Nencka, R.,Boura, E.
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14:2259-2259, 2023
Cited by
PubMed: 37080993
DOI: 10.1038/s41467-023-38019-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

221051

數據於2024-06-12公開中

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